Conference Proceeding

Nanosensor systems, Nanomedicine and mobile wireless electronics for monitoring and control of cardiovascular diseases and neurological disorders

Dr. Vijay K. Varadan,
Professor, Pennsylvania State University, USA

Dr. Vijay Varadan is currently the Twenty First Century Endowed Chair in Nano-and Bio-Technology and Medicine and Distinguished Professor of Electrical Engineering and Distinguished Professor of Biomedical Engineering (in College of Engineering) and Neurosurgery (in the College of Medicine) at the University of Arkansas. He is also a Professor of Neurosurgery at Penn State University College of Medicine. He received a B.S. in Mechanical Engineering from University of Madras(India), an M.S. in Engineering Mechanics from Penn State University, and a Ph.D. in Theoretical and Applied Mechanics from Northwestern University. He holds honorary doctorate degrees in Nano- and Bio-Technologies and Medicine from India, Australia and Finland. He is interested in the development of roll-to-roll nanoimprint technology based instrumentation, and platforming of methodologies and processes for green renewable energy, energy conversion and human health.

Nanotechnology has been broadly defined as the one for not only the creation of functional materials and devices as well as systems through control of matter at the scale of 1-100 nm, but also the exploitation of novel properties and phenomena at the same scale. Growing needs in the point-of-care (POC) that is an increasing market for improving patient’s quality of life, are driving the development of nanotechnologies for diagnosis and treatment of various life threatening diseases. This paper talk will address the recent development of nanodiagnostic sensors and nanotherapeutic devices with functionalized nanosensors on a flexible polymer based thin film electronics to monitor and control of two leading diseases namely 1) neurodegenerative diseases, 2) cardiovascular diseases. The sensors developed include implantable and biocompatible devices, light weight wearable devices in wrist-watches, hats, shoes, bra, bro, band-aid, bed sheets, pillow cases and other smart clothing. Many of these sensors are integrated with the wireless systems for the remote physiological monitoring. The author’s research team has also developed a wireless neural probe using nanowires, nanotubes and magnetic nanotubes for monitoring and control of Parkinson’s and Alzheimer’s diseases. They have demonstrated that magnetic nanotubes combined with nerve growth factor enable specific cells to differentiate into neurons. The results from in vitro studies show that magnetic nanotubes may be exploited to treat neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease because they can be used as a delivery vehicle for nerve growth factor. Light weight and compact EEG, EOG and EMG textile based monitoring system is capable of monitoring real time epileptic patients and patients with neurological and movement disorders using the Internet and cellular network. Physicians could be able to monitor these signals in real-time using portable computers, Wi-Fi, GSM or cell phones and will give early warning signal if these signals cross a pre-determined threshold level.

Published: 27 April 2017