Conference Proceeding

Marine Pharmaceutical Research in Mauritius: New perspective for anticancer therapeutics.

Dr.Theeshan Bahorun,
The marine biome has recently emerged as an untapped reservoir for the bio-prospection of structurally unique and pharmacologically active natural products. In this vein, ongoing studies aim to explore the prophylactic potentials of selected Mauritian marine floras and faunas that can spawn potential avenues in the global hunt for novel anti-carcinogenic chemotherapeutics. Using an array of established in vitro biological and chemical models, extracts from 26 marine invertebrate (7 sponge sp, 12 mollusc sp, 5 sea urchin sp, 1 ascidian sp and 1 soft coral sp) and 53 algae species (44 seaweed sp, 5 seagrass sp, 2 cyanobacteria sp and 2 mangrove sp) were analyzed for their (i) anti-oxidative propensities,(ii) anti-proliferative effects against a panel of human cancer cell lines ( 4 oesophageal, 1 liposarcoma, 1 colorectal and 1 HeLa cell line), (iii) epigenetic activities through GFP expression and (iii) total polyphenolic content as potential indicators of their biological activities. Remarkable diversity in the level of total phenolic and flavonoid content and antioxidant capacity depending onmarine species were observed. Our data showed that seaweed extracts had more pronounced antioxidant capacity and high polyphenolic contents while sponges exhibited significantly better anti-proliferative potentials particularly against FLO-1, and HeLa cell line. Concomitantly sponge extracts also demonstrated the ability to re-activate tumor suppressor genes in a heLa GFPmodel highlighting their potential role as epigenetic modulators in cancer therapy. Results reported herein suggest that Mauritian seaweeds and sponges have high potential as prophylactic sources of chemotherapeutic agents that warrant further investigation at the molecular level. This initiative is in line with the goal of the Land Based Oceanographic Industry to promote marine bio-discovery research through its vision to make the blue economy one of the economic pillars of the Republic of Mauritius.

Published: 18 July 2017

Copyright:

Copyright: © 2017 Theeshan Bahorun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.