Conference Proceeding

Biocompatible gold nanohybrid structures with tunable plasmonic and fluorescent features: syntheses, structural characterization, possible sensor and biolabelling applications

Dr. Edit Csapo,
University of Szeged, Hungary

Gold/biomolecules hybrid nanostructures having characteristic plasmonic or highly photoluminescence features have become one of the most important types of nanomaterials that have been extensively investigated in many fields.

Dr. Edit Csapó is a senior research fellow at the MTA-SZTE Supramolecular and Nanostructured Materials Research Group, Department of Medical Chemistry, University of Szeged, Hungary. She graduated as a Chemist at 2006, she has PhD degree in Chemistry from 2010. She is working in the area of nanomaterials with special interest in the biocompatible fabrication of noble metal colloids and nanosized fluorescent gold clusters. Besides the optimization of the syntheses the nanostructures have been characterized by different spectroscopic techniques. Other research interests focus on the study of the interaction between proteins and drug molecules by using surface plasmon resonance spectroscopy. She has published 31 journal papers and more than 50 conference papers (impact ca. 80, citation ca. 300.)

Gold/biomolecules hybrid nanostructures having characteristic plasmonic or highly photoluminescence features have become one of the most important types of nanomaterials that have been extensively investigated in many fields. While a number of studies have focused on protein-directed biocompatible syntheses of Au NPs or sub-nanometer sized Au NCs, there has been little focus on the fabrication of Au NPs and Au NCs using simple amino acids or small ligands. These ultra-small NCs show unique physical and chemical properties such as well-defined molecular structure, discrete electronic transitions and characteristic size tuneable photoluminescence.1Most of the protein-stabilized Au NCs exhibit intense red photoluminescence (?emission ~ 650 nm) which originates from the icosahedron gold core and partially independent from the applied protein.In this work presented here, we highlighted the biocompatible fabrications of Au NPs, Au NCs and gold(I) complexes using simple amino acids (L-His, L-Trp, L-Cys, L-Lys) and small ligands (L-Cys-Trp, adenosine monophosphate) which result in different nanostructures having tuneable blue, green, yellow and orange emissions. The main goal of this work was to investigate the spontaneous interactions of AuCl4- and the studied biomolecules as well to optimize the gold/ligand ratios and pH on the formation of gold constructs. Based on the experimental results we provided important information on the gold intermediates and the formation mechanisms of the plasmonic or fluorescent nano-objects. Moreover, the plasmonic Au NPs were used for detection of plasmon-enhanced fluorescence of hemoglobin and ferritin biomolecules while the fluorescent Au NCs and gold(I) complexes were used for biolabelling of core-shell type nanocomposite particles containing ibuprofen or selective detection of different transition metal ions (e.g. Fe3+) and anions (e.g. I-) in aqueous solutions.

Published: 27 April 2017