Conference Proceeding

Anti-angiogenesis effect of Moringa oleifera L.in Chick Chorioallantoic Membrane (CAM) Angiogenesis Assays

Mr. Pachava Vengal Rao ,
Research scholar, JSS college of Pharmacy, India

Mr. Pachava Vengal Rao completed graduation in Pharmacy and Post-graduation specialization in Pharmacology from the SRM University, Chennai, Tamilnadu. Currently he is working as a research scholar, Department of Pharmacology, JSS college of Pharmacy, Ooty, India.

The aetiology of cancer involves a multitude of biochemical and path physiological abnormalities, caused as a result of various genetic and environmental factors making it challenging to bring out an effective therapy. Amongst these, angiogenesis portrays a crucial role in the survival and subsequent metastases of tumors, eventually making it a target for anti-cancer drug discovery. Despite the availability of many drug candidates with anti-angiogenic activity, they often tend to produce complications. Based on our previous findings, ethyl acetate (EA) extract of Moringa oleifera has shown significant cytotoxicity against vero cells invitro. In the current study, EA extract of M. oleifera was employed in Chick Chorioallantoic Membrane (CAM) assay to evaluate anti-angiogenic activity. The assay was performed using 1µg, 10µg and 100µg concentrations of EA extract of M. oleifera to establish a dose response relationship. The findings revealed a significant dose dependent inhibition of angiogenesis with maximum inhibition at highest tested dose level. In conclusion, EA extract of M. oleifera demonstrated significant anti-angiogenic activity.

Published: 11 May 2017